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Optimized infection control practices augment the robust protective effect of vaccination for ESRD patients during a hemodialysis facility SARS-CoV-2 outbreak

Megan E Meller
CONCLUSIONS: Prompt recognition of an infection cluster and rapid intervention efforts successfully ended the outbreak. Alongside consistent adherence to core infection prevention measures, vaccination was highly effective in reducing disease incidence and morbidity in this vulnerable population.

Optimized infection control practices augment the robust protective effect of vaccination for ESRD patients during a hemodialysis facility SARS-CoV-2 outbreak

Megan E Meller
CONCLUSIONS: Prompt recognition of an infection cluster and rapid intervention efforts successfully ended the outbreak. Alongside consistent adherence to core infection prevention measures, vaccination was highly effective in reducing disease incidence and morbidity in this vulnerable population.

Outbreak or pseudo-outbreak? Integrating SARS-CoV-2 sequencing to validate infection control practices in a dialysis facility

Bridget L Pfaff
CONCLUSIONS: With high community prevalence, epidemiological data alone is insufficient to deem a case cluster an outbreak. Cluster evaluation with genomic data, when available with a short turn-around time, can play an important role in infection prevention and control response programs.

Pan-cancer distribution of cleaved cell-surface amphiregulin, the target of the GMF-1A3 antibody drug conjugate

Kristopher A Lofgren
Amphiregulin is a transmembrane protein which, when cleaved by the TACE/ADAM17 protease, releases a soluble epidermal growth factor receptor ligand domain that promotes proliferation of normal and malignant cells. We previously described a rabbit monoclonal antibody, GMF-1A3, that selectively recognizes the cell-associated cleaved amphiregulin epitope. Antibody-drug conjugates had anti-tumor activity against human breast cancer xenografts. Several tumor types express amphiregulin, but evidence...

The miR-23a∼27a∼24-2 microRNA Cluster Promotes Inflammatory Polarization of Macrophages

Austin Boucher
Macrophages are critical for regulating inflammatory responses. Environmental signals polarize macrophages to either a proinflammatory (M1) state or an anti-inflammatory (M2) state. We observed that the microRNA (miRNA) cluster mirn23a, coding for miRs-23a, -27a, and -24-2, regulates mouse macrophage polarization. Gene expression analysis of mirn23a-deficient myeloid progenitors revealed a decrease in TLR and IFN signaling. Mirn23a ^(-/-) bone marrow-derived macrophages (BMDMs) have an...

Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues

Kyle R Smith
Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair. Mammalian uracil-DNA glycosylases (UNG) excise deleterious uracil residues from their genomic DNA. Each herpesvirus UNG studied to date has demonstrated conservation of the enzymatic function to excise uracil residues from DNA. We previously reported that a murine gammaherpesvirus (MHV68) with a stop codon in ORF46 (ORF46.stop) that...

Uracil-DNA Glycosylase of Murine Gammaherpesvirus 68 Binds Cognate Viral Replication Factors Independently of its Catalytic Residues

Kyle R Smith
Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair. Mammalian Uracil-DNA glycosylases (UNG) excise deleterious uracil residues from their genomic DNA. Each herpesvirus UNG studied to date has demonstrated conservation of the enzymatic function to excise uracil residues from DNA. We previously reported that a murine gammaherpesvirus (MHV68) with a stop codon in ORF46 (ORF46.stop) that...
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Advanced GI MIS/Bariatric Surgery Fellows & Alumni
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You’ll spend a year learning our multi-disciplinary approach to bariatric patients and practicing advanced laparoscopic and robotic procedures. Our fellows graduate prepared to establish a minimally invasive bariatric surgery or foregut program in an academic environment or private practice.
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Advanced GI MIS/Bariatric Surgery Fellowship Research
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During your fellowship, you’ll engage in 2 research activities to grow your knowledge, advance the specialty and improve patient care.
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Advanced GI MIS/Bariatric Surgery Fellowship Faculty
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You’ll be inspired by our distinguished program faculty and cross-departmental team who are invested in your training and success.
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Notice of Non-Discrimination
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At Gundersen Health System we respect your right to high quality care with dignity, respect and appreciation of the beliefs and values of each patient. We care for patients without regard to: age, race, ethnicity, ancestry, national origin, creed, religion, culture, language, physical or mental disability, newborn status, socioeconomic status, marital status, sex, sexual orientation, gender identity or expression. That commitment also applies to our regional center locations.
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Financial Assistance
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Gundersen Health System provides medically necessary care regardless of ability to pay. We can provide financial assistance for medical expenses that you or your family accumulate at any of our facilities. If you believe you may be eligible for Financial Assistance we encourage you to apply. Financial assistance application forms can be completed at no charge in MyChart or can be downloaded below.
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Wait Times
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See the wait time for our ExpressCare Clinic in La Crosse.
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Care Options
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Online or in-person, we have your healthcare covered.
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DOT Supervisor training registration
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Please fill out the form below to register for the DOT Supervisor Drug & Alcohol Training program.
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Gundersen Lutheran Emergency and Urgent Care
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When you have an illness or injury that is serious or life-threatening, call 911 or your local emergency number, or go directly to Gundersen Emergency Services in La Crosse or the nearest emergency department. It can be hard to know if you need emergency care or urgent care. Emergency Services in La Crosse handles both urgent care cases and emergencies/traumas. Specially trained Emergency Services staff will get you to the right level of care.

1900 South Ave.
La Crosse, WI 54601

(608) 782-7300
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